Vasectomy immobilizing antibodies against sperm clumps

Evidence for active immunological regulation in prevention of testicular autoimmune disease independent of the blood-testis barrier. The management of infertile men presenting in the assisted conception unit. Because sperm that are antibody bound over most of their surfaces are unable to enter cervical mucus 53 antibody binding to the sperm tail tip being a possible exception 54 , yet they remain completely motile in semen, several studies have shown a relationship between antisperm antibodies and impaired results of postcoital tests. Antigen specific immunoglobulin in prostatic fluid. Operative approaches and technical details of reconstructive methods are described, fundamental for successful results. In mice traumatized with mg. Potential causes of male factor infertility are many and require thorough evaluation for their accurate elucidation.
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The effects of sperm antibodies on fertility after vasectomy reversal. - PubMed - NCBI

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[Haematology] Atlas of Semen Analysis

Incidence of lymphocytotoxins in vasectomy patients—a prelminary report. Associations identified in studies using this methodology often appear more highly significant than they actually are owing to the potential for various forms of bias. J Nerv Ment Dis Approaches to the control of fertility based on immunological.
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Long-Term Risks of Vasectomy

In most patients, a similar amount of sperm immobilizing antibodies was present in the peritoneal fluid and the sera. Int J Epidermiol The relation of vasectomy to the risk of cancer. Thus, despite isolated findings of a significant association of vasectomy with changes in some hormones, the bulk of the extensive research on the subject provides strong evidence that vasectomy has no effect on testosterone or the pituitary gonadotropins at least up to 25 years after the operation. Immunologic studies in long-term follow-up of vasectomized men.
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Acquired blocks of cauda epididymis 34 cases and vas 23 cases were significantly more commonly associated with serum antisperm antibodies than congenital bilateral absence of vasa 29 cases or blocks at the caput epididymis 48 cases , most of which were associated with sinusitis, bronchitis or bronchiectasis Young's syndrome. Hence, overnight postcoital testing provides a clearer indication of antibody-mediated sperm damage than does a shorter interval 2 hours after sex. Because this assay lends itself clinically to rapid analysis of larger numbers of sera, it has been a favorite in commercial laboratories. This means that IgA antibodies to any antigen expressed on the sperm membrane will impair penetration and that, in this situation, the immunoglobulin class of the ASA becomes more important than the antigen specificity. Rabbits immunized with fertile men's sperm extract and seminal plasma had significantly elevated postimmunization hemagglutinating but not cytotoxic sperm antibodies and reproduced normally. A defined group of 20 women suffering recurrent spontaneous abortions of unknown etiology was studied for determinants relevant to immune responsiveness. Abnormal expression of certain sperm proteins may play a role in failure of fertilization resulting in unexplained male infertility at clinical level.
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